Science | S-Quatre Corporation

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What’s SHED?
SHED：Stem cells from
Human Exfoliated Deciduous teeth

SHED are mesenchymal stem cells (MSC) isolated from the baby tooth pulp and quite different from widely studied MSCs derived from bone marrow or adipose tissue in the following two points:

1) Higher proliferative capacity due to the young donor age
2) Higher producibility of neurotrophic factor due to its derivation from ectodermal neural crest cells.

SQ-SHED (SHED isolated and cultured by our own methods) demonstrated an even higher growth rate and producibility of various trophic factors. We have confirmed the potent effects of SQ-SHED in several animal models including cerebral palsy, spinal cord injury, intractable bone defects, and critical limb ischemia.

DPSC, Dental pulp stem cells from adult teeth
BMSC, Bone marrow derived MSC
ATSC, Adipose tissue derived MSC

SQ-SHED exhibit a unique gene expression profile enriched for
“Nerve growth”, “Angiogenesis”, and “Cell migration”,
which are quite important for tissue regeneration.

Each plot represents a separate donor

DPSC, Dental pulp stem cells from adult teeth
BMSC, Bone marrow derived MSC
ATSC, Adipose tissue derived MSC
NDF, Neonatal Human Dermal Fibroblasts

Microarray Study

SQ-SHED produce much higher amounts of protein factors related to
“Nerve growth”, “Angiogenesis”, and “Cell migration”,
compared to other MSCs consistent with the results of gene ontology analysis.

Each plot represents a separate donor

Secretion of Protein Factors Related to the Enriched GO

SQ-SHED produce higher amounts of trophic factors associated with
“Nerve growth”, and “Angiogenesis”
than SHED cultured in FBS or other commercial media.

Advantage of SQ Methods of Manufacturing

What’s SHED? SHED：Stem cells from Human Exfoliated Deciduous teeth

What’s SHED?
SHED：Stem cells from
Human Exfoliated Deciduous teeth